Purchase Hcg Injections
Human Chorionic Gonadotropin (HCG injections) is a hormone usually produced by the human placenta, and is often called as “Pregnancy hormone”. This hormone is detected in blood and urine of pregnant women in the form of pregnancy tests. In pregnancy this hormone stimulates progesterone production which in turn supports and maintains pregnancy.
Although it is naturally produced during pregnancy, the hormone has been extracted from the urine of pregnant women, and used as a medication for several health conditions. The Food and Drug Administration (FDA) has approved the use of HCG for different indications in males and females, including the fertility treatment for both.
HCG supports the normal development of egg in the ovaries of females, and also stimulates the release of egg during ovulation. Therefore it has been used to induce ovulation and thus treating female infertility.
It has also shown to increase sperm count in males. Furthermore, hCG can be used in young boys whose testes has not descended normally into the scrotum. It can also enhance the normal sexual development in boys by stimulating the testes to release the male sex hormone (testosterone). HCG is available under the brand names like Ovidrel and Pregnyl.
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What is HCG injection?
Human chorionic gonadotropin (hCG) is a hormone produced during the early pregnancy by the specialized cells called trophoblasts, within the placenta. This hormone maintains adequate levels of progesterone which thereby supports the pregnancy.
HCG injection is a derivative of such hormone, which is manufactured in the form of recombinant human chorionic gonadotropin. It belongs to the pharmacotherapeutic group of ‘sex hormones and modulators of genital system’. This injection is used for parenteral administration indicated in several conditions such as treating infertility in males and females.
How does it work?
Human chorionic gonadotropin (hCG) is released in the placenta by the trophoblast cells. This hormone binds to the theca and granulose cells of the ovaries to a transmembrane receptor which is also shared with the luteinizing hormone (LH/CG receptor).
Therefore, it acts as a surrogate luteinizing hormone (LH) which stimulates ovulation. The various actions of this hormone include oocyte meiosis resumption, follicular rupture (ovulation), formation of corpus luteum, and the production of estradiol and progesterone by the corpus luteum.
HCG is specifically used to stimulate the final follicular maturation and early luteinisation, following the use of other medical products for the follicular growth stimulation. For instance, when there is a mature egg follicle in the ovary, HCG injection can stimulate the egg maturation and release.
Use of HCG injection
The commonest indication for hCG injection, which is FDA-approved, is the treatment of infertility in women. Since hCG acts like LH and aids in ovulation, this hCG injection can be used in the ovulation induction cycle for the purpose of intrauterine insemination (IUI) or in-vitro fertilization (IVF).
Ovulation occurs approximately 36 hours after hCG injection, which allows considerable time for the healthcare professional to retrieve egg or for intrauterine insemination. Sometimes, hCG is given in combination with other drugs like menotropin and urofollitropin to boost the fertility and stimulate the follicular growth.
Hence, hCG finds its extensive application in the assisted reproductive techniques (ART). Furthermore, it can also be used to trigger ovulation and luteinisation in anovulatory and oligo-ovulatory women.
hCG injection can also be used for male fertility, especially in adult men with hypogonadism, wherein there is an inadequate production of male sex hormone – testosterone. Thus by stimulating testosterone production, it increases the sperm count, and helps in patients with infertility due to low sperm count.
HCG injection has also used in young boys whose testes have failed to descend into the scrotum normally, as found in certain pituitary gland disorders.
How to Use HCG Injection?
Human Chorionic Gonadotropin is a hormone present in the human body at different levels. It is an FDA-approved hormone used for both men and women to treat fertility issues. You may need more than 5,000 units of HCG for treatments, like In- vitro fertilization.
On the contrary, men with low sperm count need not more than 4,000 units of HCG. While women have to take subcutaneous and intramuscular injections, men should inject the hormone into muscles. Thus, you have to use the HCG injection based on the issues.
Some of us inject the hormone directly your muscles using a needle of 22.5-gauge. It ensures the absorption of hormones within a short time. But you may feel slight pain in this case. Still, there is no risk of bleeding and other issues.
How to use HCG injections?
- Make sure that you have essentials, like bandages, alcohol wipes, liquid HCG, syringes, needles, and gauze.
- Clean your hands with a soapy solution. Wipe down the chosen site (where you like to inject HCG) using an alcohol wipe. Wait until the site is dry.
- Ensure that your syringe has no air while holding the needle upright. Remove air bubbles and push down the plunger.
- Hold your skin gently to grab the fat and the skin.
- Press your plunger slowly and empty the needle into the fat layer.
- Pull out the needle. Never rub the injection site.
- Throw away your syringe and needle.
Thus, these are the ways of using hCG injection.
This medication is given by a qualified healthcare professional (doctor/nurse). If it is taken by the user at home, they must go through the instructions thoroughly and consult with the doctor/pharmacist whenever required.
This product must be visually checked for particles or discoloration. The dosage is based on the user’s age, weight, medical condition, and treatment response. The instructions regarding the use of pre-filled syringes or reconstitution of the powder form into appropriate dosages must be sought by the user from the pharmacist/doctor.
Information about the storage and discarding of medicines must be provided to the users. The powder form of hCG must be with the sterile water provided in the package. It is then mixed and loaded into the syringe for injection at appropriate sites.
The plunger of syringe is gently pushed till there is no air or bubbles left in the syringe. Furthermore, the proper technique of injecting subcutaneously or intramuscularly must be demonstrated.
Before the treatment is started, the couple’s infertility must be assessed and putative contraindications for pregnancy must be evaluated.
The medication must be stopped at once and doctor’s consultation taken if the user develops allergic reaction to this injection, such as breathing difficulty, rashes, hives, swelling of face, lips, and tongue. If the patients develop features of blood clot, such as, warmth, redness, tingling/numbness of arms/legs, dizziness, confusion, and headache.
Ovarian hyperstimulation syndrome (OHSS) can occur in some patients, especially after the first cycle, which is a potentially life threatening condition. This condition may be seen in those with polycystic ovarian syndrome, and is self-subsiding. OHSS is characterized by the following features:
- Swelling of hands/legs
- Severe pelvic pain
- Breathing difficulty
- Abdomen pain and swelling/distension
- Weight gain
- Ovarian enlargement
- Oliguria or reduced urination
- Electrolyte imbalances
- Ovarian hyperstimulation syndrome (OHSS)
- Stomach pain
Other minor side-effects caused by hCG injection include: headache, restlessness, irritability, edema, depression, tiredness, breast swelling or tenderness, and injection site reactions. Furthermore, hCG injections can cause early puberty in young boys, showing features like deepening of voice, pubic hair growth, acne and increased sweating.
When Not to use it?
Following conditions are the contraindications for use of hCG injections:
- Hypersensitivity reaction to medication or its components
- Pituitary gland or hypothalamus tumours
- Enlargement of ovaries
- Cancer of the ovary, uterus or breast
- Hormone-related cancers (like prostate cancer)
- Gynecological bleeding (haemorrhages) of unknown causes
- Underlying thromboembolic disorders
- Uncontrolled thyroid/adrenal dysfunction
- Currently pregnant
Relative contraindications for hCG injection includes: primary ovarian failure, uterine diseases which are incompatible with pregnancy (malformations, fibroid tumours), and post-menopausal women.
Warnings for special population:
HCG injection is not indicated if the patient is already pregnant. It is classified as category X with potential teratogenic effects. However, there is limited data suggesting the risk of malformations or foetal toxicities in exposed pregnant women.
Although there is no data regarding excretion of this medication in breast milk, it is not indicated during breastfeeding.
There is no data regarding harmful effects in elderly, though there are no indications for elderly population.
Safety and efficacy in children below 4 years of age, has not been established.
It is noteworthy that hCG injection can only help the woman to become pregnant, but it may harm the baby if taken when the woman is already pregnant. Hence, if the pregnancy is confirmed, this injection is avoided. One must not use hCG injections in larger doses or longer durations than recommended.
One must consult their doctor before initiating treatment with this injection and inform the doctor about any existing health conditions including: asthma, hCG allergy, hormone-related diseases, heart diseases, kidney diseases, migraines, precocious puberty, epilepsy, uterine bleeding, and cancer of breast/uterus/ovaries/prostate/hypothalamus/pituitary gland.
If any of these conditions are present, then dose adjustments or further evaluations may be necessary before initiating hCG treatment. In case of occurrence of any adverse event with this medication, the patients must report it and consult their doctor.
If the patient is on assisted reproduction therapy, then the possibility of multiple pregnancy, pregnancy loss, ectopic pregnancy, congenital malformations, thromboembolic events, neoplasm of reproductive system may be discussed for user awareness. There is a possibility of interference with serum/urinary testing leading to false positive pregnancy tests.
The maximum dosage is 250 micrograms. One pre-filled syringe contains 250 mcg of hCG in 0.5mL, equivalent to about 6500 IU. One injection is given subcutaneously or intramuscularly, after optimal stimulation of follicular growth is achieved (by FSH or other medications). In female infertility, 5000 to 10000 IU is injected at regular schedule as determined by the doctor. In male infertility, 1000 to 4000 IU of hCG is injected intramuscularly 2-3 times a week for several weeks or months.
In case of missed dosage or over dosage, one must immediately consult the doctor, especially if they develop severe symptoms like breathing difficulty and other features of OHSS.
Interactions with alcohol and food:
There are no restrictions on food, beverage or activities while using this medication.
Interactions with medicines:
Certain drugs may interact with hCG. Hence the user must inform the doctor about the use of all the prescriptions and over-the-counter drugs, including nutritional supplements, herbal products, and other. Gonadorelin is a drug known to interact with hCG. Furthermore, this medication may interfere with the laboratory testing of FSH/LH levels, giving false results.
Interactions with health conditions:
Safety and efficacy of hCG injections in renal and hepatic diseases have not been established. Patients with history of thromboembolic events can have aggravations with hCG injections. Patients with reproductive system neoplasm tend to have increased risk for such cancers with the use of hCG. Patients on prolonged ART may have possibility of pregnancy loss, ectopic pregnancy, multiple pregnancy, and congenital malformations.
How to store it?
The pre-filled syringe must be stored in a refrigerator (2°C – 8°C) in its original package. The shelf-life is about 2 years. Within its shelf-life, it can be stored at <25°C for upto 30 days without refrigeration; but must be discarded if used beyond 30 days.
If one receives the liquid form of hCG injections from pharmacy, it must be stored in refrigerator within 3 hours, until it is ready to be used. hCG injections must not be used without refrigeration.
hCG in powder form may be stored at room temperature, and reconstituted with sterile water while using it.
It should be kept away from children, and it should not be shared with others. It is to be used only for the prescribed indication as per doctor’s advice.
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